Fluidized Bed System

Full fluidization is guaranteed with the unique revolutionary swirl generating method which gives great uniformity of coverage and high returns to the end product. The major difficulty is how optimal and uniform granule covering may be achieved. All grains engaged in the process of coating should have the same coating thickness, irrespective of their size.

In addition to handling aqueous as well as organic film coating systems, an advanced control panel helps you to monitor and record all the settings for the Fluid bed processor.

The chamber generally is a vertical cylinder in a fluidized bed processor. A column of air that flows up from the lower center of the cylinders fluidizes the pellets. The tablets in the center travel upward and downwards through the chamber wall, from the base of the column into the air stream again. In the base and top of the chamber, there are spray nozzles used to insert the coating solution.

The core of the pellet is fragile, abrasive, and tearing-prone, which makes it difficult even under optimal conditions to completely coat the tablet. This is due to the tablet-to-tablet collision as well as the contact between the tablet chamber and the tablet.

Two main configurations are utilized to implement fine tablet coating solutions:

1.    High-Pressure Airless System

Airless spray fluid is pushed into a small orifice between 0.02 and 0.2 mm in diameter at the high pressure of 1.7 to 20 MPa (250 to 3000 Psi) to produce a fine spray. The atomization degree and the spray rate are all regulated by fluid pressure, viscosity, and size of the aperture.

2.    Low-Pressure Atomized Air Systems

The liquid is pushed through a wider opening between 0.05 and 2.5 mm in diameter with a relatively low pressure of 35 – 350 kPa (5 to 50 psi). At the top of the atomizer, the low-pressure air reaches the liquid stream and a finely distributed spray pattern is created. The degree of atomization is determined by the size of the aperture, fluid viscosity, fluid pressure, air cap design, and air pressure.

 

Operation

 

1.    Bottom-Spray Coating (Wurster coating)

This processing option uses the energy and controls the fluidized bed processor to create a pneumatic mass transport inside a special insert, which is consisted of a perforated bottom screen with defined free areas.

This uniform statistical residence time of all particles in the coating zone results in a very uniform coating. Due to the high kinetic energy provided by the pneumatic mass flow moist particles are separated, as such allowing the individual coating of even very small particles. Due to the nozzle being positioned directly inside the product and concurrently spraying a premature viscosity change of the coating droplet is avoided. All these features result in the highest possible coating quality, which is imperatively required to produce defined and reproducible drug delivery profiles.

2.    Top-Spray Coating

Spray coating can be used for all fluid bed systems, be it in batch or continuous operation or if the film is applied from a sprayed solution or suspension. For this processing option from the parameters has to be chosen to avoid agglomeration, i.e. liquid bridges between the air suspended particles.

If spraying a solution or suspension the liquid only serves as a vehicle to deliver the coating material to the surface of the substrate. The quality of the coating extensively depends on the statistical residence time of the particles in the coating zone. In classic fluid bed equipment only top-spray coating is possible. Bottom- spray arrangement can be made by the replacement of container. A perfect film is generally not required for this function, but care must be taken that the droplets should not be too viscous before touching the substrate, in order to maintain a good spreadability. As however neither the particle motion, nor the travel distance of droplet from the nozzle to substrate is uniform, the film structure is generally rather porous, but nevertheless measuring up to the above-described requirements.

Comments

Post a Comment

Popular posts from this blog

How to Choose the Right Fluid Bed Processor for Your Needs

In the world of pharmaceuticals, chemicals, and food processing, the choice of equipment can greatly impact the quality and efficiency of your production processes. One such crucial piece of equipment is the fluid bed processor  for granulation . Whether you are in the pharmaceutical industry looking to granulate powders or involved in other industries requiring particle coating or drying, selecting the right fluid bed processor is paramount. In this comprehensive guide, we will walk you through the key factors to consider when choosing the perfect fluid bed processor for your specific needs.   Understanding Fluid Bed Processors  for granulation Before we dive into the selection process, let's briefly understand what a fluid bed processor  for granulation  is and what it does. A fluid bed processor is a versatile piece of equipment used for a wide range of applications such as drying, granulation, coating, and pelletization of powders or granules. It works by su...
Read more

The Functions of the Water Maze, Fluid Bed Dryer, & Plethysmometer in Research

In science, particular tools and techniques are often employed in an attempt to understand and increase our knowledge. These tools are crucial for a wide range of research applications. Three examples are the plethysmometer, fluid bed dryer, and water maze. In this comprehensive review, we'll look at the significance of these instruments, their applications, and how they advance scientific findings.   Plethysmometer Tracking Volume Changes What is a plethysmometer? The plethysmometer  is an advanced instrument used in several scientific fields, including physiology and pharmacology. Its unique purpose is to measure fluctuations in volume, often found in live organisms.   In what way does a plethysmometer work? Among the most common forms of plethysmometers are pneumotachometers, which are used to measure changes in lung volume in humans or animals. It operates under the premise that the movement of air, which results in a change in volume, may be used to identify an organ...
Read more

In-Depth Guide to Ball Mill Machine, Tablet Coater, & Double Cone Blender in Manufacturing

The modern manufacturing industry relies heavily on advanced machinery to streamline production processes and ensure the highest quality output. Among the key players in this landscape are the Ball Mill Machine, Tablet Coater, and Double Cone Blender. In this comprehensive guide, we will delve deep into these three pivotal pieces of equipment, exploring their working principles, applications, and advantages in the world of manufacturing.   1. Ball Mill Machine 1.1 Working Principle The  Ball Mill Machine  is a versatile workhorse in various industries, including pharmaceuticals, chemicals, and mining. At its core, the ball mill operates on a fundamental principle – that of impact and attrition. A cylindrical shell, mounted horizontally, houses the material to be ground along with the grinding medium, typically steel balls. As the shell rotates, the balls cascade within, impacting and grinding the material, ultimately reducing it to a fine powder.   1.2 Applications P...
Read more