Hot Melt Extruder

The extruder is widely used for making pellets of different sizes starting from a minimum of 400 microns to a maximum of 2000 microns. Extruder gives mild compaction and is ideal for most pharmaceutical formulations related to palletization. The function of a spheronizer is to convert extrudes into spheroids. Spheronization is the necessary second step of granulation by extrusion – spheronization process where pharmaceutical products are made into small spheres or spheroids Activate the machine and load the pre-formulated wet mass into the feed funnel(Hopper). The material is forced through the extrusion chamber to cone mesh by axial force of Counter-rotating screws. Conical pressing roller forces the material through the perforations of Single cone mesh and the extrude formed.

Hot Melt Extruder is a modification of screw extruders. A carefully controlled heater heats the barrel which conducts the heat to the product. The molten polymeric mass is extruded from the die plates.

Application:

  •  Hot Melt Extruder is widely used for making pellets of different sizes starting from a minimum of 400 microns to a maximum of 2000 microns.
  • Extruder gives mild compaction and is ideal for most pharmaceutical formulations related to palletization.
  • The extruder consists of Hopper for loading of wet mass, Hopper as internal blades connected to gear to rotate and systematically push the material into the feed hopper of Extruder Chamber, Extrusion chamber is Jacketed from outside for circulation of cold water to maintain the temperature of the product, in case the product is sensitive in nature.
  • The extrusion chamber consists of a single screw that transfers the material towards the pressing cam and out from the perforation of the screen of the desired dia.
  • Hot Melt Extruder is available from R&D batches with a minimum output of 250 gms.
  • The extruder is cGMP complied equipment with self-standing Table Top Model for R&D scale which controls operation with built-in electrical panel for ease in maintenance.

Advantages:

  • Pellets dosage forms have a distinct advantage in the pharmaceuticals industry.
  • Having the flexibility of solution/ suspension layering and powder layering
  • Minimal dust in the process environment
  • Improved flow characteristics
  • Improved solubility and dispersibility
  • Improved Cosmetics.

Comments

Post a Comment

Popular posts from this blog

How to Choose the Right Fluid Bed Processor for Your Needs

In the world of pharmaceuticals, chemicals, and food processing, the choice of equipment can greatly impact the quality and efficiency of your production processes. One such crucial piece of equipment is the fluid bed processor  for granulation . Whether you are in the pharmaceutical industry looking to granulate powders or involved in other industries requiring particle coating or drying, selecting the right fluid bed processor is paramount. In this comprehensive guide, we will walk you through the key factors to consider when choosing the perfect fluid bed processor for your specific needs.   Understanding Fluid Bed Processors  for granulation Before we dive into the selection process, let's briefly understand what a fluid bed processor  for granulation  is and what it does. A fluid bed processor is a versatile piece of equipment used for a wide range of applications such as drying, granulation, coating, and pelletization of powders or granules. It works by su...
Read more

The Functions of the Water Maze, Fluid Bed Dryer, & Plethysmometer in Research

In science, particular tools and techniques are often employed in an attempt to understand and increase our knowledge. These tools are crucial for a wide range of research applications. Three examples are the plethysmometer, fluid bed dryer, and water maze. In this comprehensive review, we'll look at the significance of these instruments, their applications, and how they advance scientific findings.   Plethysmometer Tracking Volume Changes What is a plethysmometer? The plethysmometer  is an advanced instrument used in several scientific fields, including physiology and pharmacology. Its unique purpose is to measure fluctuations in volume, often found in live organisms.   In what way does a plethysmometer work? Among the most common forms of plethysmometers are pneumotachometers, which are used to measure changes in lung volume in humans or animals. It operates under the premise that the movement of air, which results in a change in volume, may be used to identify an organ...
Read more

In-Depth Guide to Ball Mill Machine, Tablet Coater, & Double Cone Blender in Manufacturing

The modern manufacturing industry relies heavily on advanced machinery to streamline production processes and ensure the highest quality output. Among the key players in this landscape are the Ball Mill Machine, Tablet Coater, and Double Cone Blender. In this comprehensive guide, we will delve deep into these three pivotal pieces of equipment, exploring their working principles, applications, and advantages in the world of manufacturing.   1. Ball Mill Machine 1.1 Working Principle The  Ball Mill Machine  is a versatile workhorse in various industries, including pharmaceuticals, chemicals, and mining. At its core, the ball mill operates on a fundamental principle – that of impact and attrition. A cylindrical shell, mounted horizontally, houses the material to be ground along with the grinding medium, typically steel balls. As the shell rotates, the balls cascade within, impacting and grinding the material, ultimately reducing it to a fine powder.   1.2 Applications P...
Read more